ISPConfig 3.0.4.3: the "Add new Webdav user" can chmod and chown entire server from client interface.
PHP remote file inclusion vulnerability in session.inc.php in ISPConfig 2.2.2 and earlier allows remote attackers to execute arbitrary PHP code via a URL in the go_info[server][classes_root] parameter. NOTE: the vendor has disputed this vulnerability, saying that session.inc.php is not under the web root in version 2.2, and register_globals is not enabled
ISPConfig before 3.2.2 allows SQL injection.